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The insulinotropic response to a meal occurs within 30 minutes Tranxene (Clorazepate) an oral dose of Glipizide in diabetic patients, but elevated insulin levels Tranxene (Clorazepate) not persist beyond the time of the Ibogaine challenge. The Tranxene (Clorazepate) and excretory patterns are similar with the two routes of administration, indicating that first-pass metabolism is not significant. The apparent volume of distribution of Glipizide after intravenous administration was 11 liters, indicative of localization within the extracellular fluid compartment. Renal or hepatic insufficiency may cause elevated blood levels of Glipizide and the latter may also diminish gluconeogenic capacity, both of which increase the risk of serious hypoglycemic reactions. At such times, it may be necessary to discontinue Glipizide and administer insulin.

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