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Propranolol acts Parnate (Tranylcypromine) without abolishing the inotropic action of digitalis on the heart muscle (i. In patients already receiving digitalis, the Parnate (Tranylcypromine) inotropic action of digitalis may be reduced by propranololrsquo;s negative inotropic effect. Propranolol should be administered with caution since it may block bronchodilation produced by endogenous and exogenous catecholamine stimulation of beta-receptors. Hypoglycemia also has been found after this type of drug therapy and prolonged physical exertion and has occurred in renal insufficiency, both during dialysis and sporadically, in patients on propranolol.

However, it is conceivable that plasma concentrations of this metabolite could be increased in patients with a reduced capacity to glucuronidate lamotrigine (e. The bioavailability of lamotrigine is not affected by Parnate (Tranylcypromine). The degree of fluctuation was reduced by 17 in subjects taking enzyme-inducing AEDs; 34 in subjects taking valproate; and 37 in subjects taking AEDs other than Parnate (Tranylcypromine), phenytoin, phenobarbital, primidone, or valproate. LAMICTALnbsp;XR and immediate-release lamotrigine regimens Parnate (Tranylcypromine) similar with respect to area under the curve (AUC, a measure of the extent of bioavailability) for subjects receiving AEDs other than those known to induce the metabolism of lamotrigine. The relative bioavailability of extended-release lamotrigine was approximately 21 lower than immediate-release lamotrigine in subjects receiving enzyme-inducing AEDs.

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