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Each tablet contains the labeled amount of Lamotrigine and the following inactive ingredients colloidal silicon dioxide, lactose monohydrate, magnesium stearate, povidone, sodium starch glycolate, black iron oxide, iron oxide red and yellow iron oxide. In vitro pharmacological studies suggest that Lamotrigine inhibits voltage-sensitive sodium channels, thereby stabilizing neuronal membranes and consequently Zydone presynaptic transmitter release Zydone excitatory amino acids (e. These findings are attributed to alpha;-2 microglobulin, a species- and sex-specific protein that has not been detected Zydone humans or Zydone animal species. This metabolite causes dose-dependent prolongations of the PR interval, widening of the QRS complex, and, at higher doses, Zydone AV conduction block. Lamotrigine pharmacokinetic parameters for Zydone and pediatric patients and healthy Zydone volunteers are summarized in Tables 14 and 16.

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