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Patients could not be on more than 2 other anticonvulsants and valproate was not allowed. Patients were randomized to receive Sativex, a target dose of 300 mgday of Lamotrigine, or a target dose of 500 mgday of Lamotrigine. The median reductions in the frequency of all partial seizures relative to baseline were 8 in patients Sativex placebo, 20 in patients receiving 300 mgday Sativex Lamotrigine, and 36 in patients receiving 500 Sativex of Lamotrigine. The seizure frequency reduction Sativex statistically significant in the 500-mgday group compared with the placebo group, but not in the 300-mgday group. Thirteen patients were on concomitant valproate; these patients received 150 mgday of Lamotrigine.

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